Regulation of Apoptosis during Environmental Skin Tumor Initiation

Authors

Bilal B. Hafeez, The University of Texas Rio Grande ValleyFollow
Eunmi Park, Hannam University
Kyung-Soo Chun, Keimyung University
Yong-Yeon Cho, The Catholic University of Korea
Dae Joon Kim, The University of Texas Rio Grande ValleyFollow

Document Type

Book Chapter

Publication Date

4-26-2021

Abstract

Skin cancer is more prevalent than any other cancer in the United States. Nonmelanoma skin cancers are the more common forms of skin cancer that affect individuals. The development of squamous cell carcinoma, the second most common type of skin cancer, can be stimulated by exposure of environmental carcinogens, such as chemical toxicants or UVB. It is developed by three distinct stages: initiation, promotion, and progression. During the initiation, the fate of DNA-damaged skin cells is determined by the homeostatic regulation of pro-apoptotic and antiapoptotic signaling pathways. The imbalance or disruption of either signaling will lead to the survival of initiated cells, resulting in the development of skin cancer. In this chapter, we will discuss signaling pathways that regulate apoptosis and the impact of their dysfunction during skin tumor initiation.

Comments

© 2021 The Author(s). Licensee IntechOpen.

Recommended Citation

Hafeez, B. B. , Park, E., Chun, K., Cho, Y., & Kim, D. J. (2021). Regulation of Apoptosis during Environmental Skin Tumor Initiation. In (Ed.), Regulation and Dysfunction of Apoptosis. IntechOpen. https://doi.org/10.5772/intechopen.97542

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

Publication Title

Regulation and Dysfunction of Apoptosis

DOI

10.5772/intechopen.97542

Academic Level

faculty

Mentor/PI Department

Immunology and Microbiology