School of Medicine Publications and Presentations
Document Type
Article
Publication Date
4-26-2021
Abstract
Skin cancer is more prevalent than any other cancer in the United States. Nonmelanoma skin cancers are the more common forms of skin cancer that affect individuals. The development of squamous cell carcinoma, the second most common type of skin cancer, can be stimulated by exposure of environmental carcinogens, such as chemical toxicants or UVB. It is developed by three distinct stages: initiation, promotion, and progression. During the initiation, the fate of DNA-damaged skin cells is determined by the homeostatic regulation of pro-apoptotic and antiapoptotic signaling pathways. The imbalance or disruption of either signaling will lead to the survival of initiated cells, resulting in the development of skin cancer. In this chapter, we will discuss signaling pathways that regulate apoptosis and the impact of their dysfunction during skin tumor initiation.
Recommended Citation
Hafeez, B. B. , Park, E., Chun, K., Cho, Y., & Kim, D. J. (2021). Regulation of Apoptosis during Environmental Skin Tumor Initiation. In (Ed.), Regulation and Dysfunction of Apoptosis. IntechOpen. https://doi.org/10.5772/intechopen.97542
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Publication Title
Regulation and Dysfunction of Apoptosis
DOI
10.5772/intechopen.97542
Academic Level
faculty
Mentor/PI Department
Immunology and Microbiology
Comments
© 2021 The Author(s). Licensee IntechOpen.