Normal-tension glaucomatous optic neuropathy is related to blood pressure variability in the Maracaibo Aging Study

Authors

Jesus D. Melgarejo, The University of Texas Rio Grande ValleyFollow
Gladys E. Maestre, The University of Texas Rio Grande ValleyFollow
Luis J. Mena
Joseph H. Lee
Michele Petitto
Carlos A. Chavez
Gustavo Calmon
Egle Silva
Lutgarde Thijs
Lama A. Al-Aswad, New York University School of Medicine

Document Type

Article

Publication Date

9-2021

Abstract

Hypoperfusion of the optic nerve might be involved in the pathogenesis of normal-tension glaucomatous optic neuropathy (GON). Mean arterial pressure (MAP) drives ocular perfusion, but no previous studies have addressed the risk of GON in relation to blood pressure (BP) variability, independent of BP level. In a cross-sectional study, 93 residents of Maracaibo, Venezuela, underwent optical coherence tomography, visual field assessments and 24-h ambulatory BP monitoring between 2011 and 2016. We investigated the association of normal-tension GON with or without visual field defects with reading-to reading variability of 24-h MAP, as captured by variability independent of the MAP level (VIMmap). Odds ratios (ORs) were adjusted for 24-h MAP level and for a propensity score of up to five risk factors. Among the 93 participants (87.1% women; mean age, 61.9 years), 26 had open-angle normal-tension GON at both eyes; 14 had visual field defects; and 19 did not have visual field defects. The OR ratios for normal-tension GON, expressed per 1-SD increment in VIMmap (2 mm Hg), were 2.17 (95% confidence interval, 1.33–3.53) unadjusted; 2.20 (1.35–3.61) adjusted for 24-h MAP level only; 1.93 (1.10–3.41) with additional adjustment for age, educational attainment, high-density lipoprotein (HDL) cholesterol and office hypertension; and 1.95 (1.10–3.45) in models including intraocular pressure. We confirmed our a priori hypothesis that BP variability, most likely operating via hypoperfusion of the optic nerve, is associated with normal-tension GON. 24-H ambulatory BP monitoring might therefore help stratify the risk of normal-tension GON.

Recommended Citation

Melgarejo, J. D., Maestre, G. E., Mena, L. J., Lee, J. H., Petitto, M., Chávez, C. A., Calmon, G., Silva, E., Thijs, L., Al-Aswad, L. A., Terwilliger, J. D., De Moraes, C. G., Wei, F. F., Vanassche, T., Verhamme, P., Staessen, J. A., & Zhang, Z. Y. (2021). Normal-tension glaucomatous optic neuropathy is related to blood pressure variability in the Maracaibo Aging Study. Hypertension research : official journal of the Japanese Society of Hypertension, 44(9), 1105–1112. https://doi.org/10.1038/s41440-021-00687-1

DOI

10.1038/s41440-021-00687-1

Academic Level

faculty

Mentor/PI Department

Neuroscience