Non-congenital severe ocular complications of Zika virus infection

Authors

Mussaret B. Zaidi
c Gustavo De Moraes
Michele Petitto
Juan B. Yepez
Anavaj Sakuntabhai
Etienne Simon-Loriere
Matthieu Prot
Claude Ruffie
Susan S. Kim
Gladys E. Maestre, The University of Texas Rio Grande ValleyFollow

Document Type

Article

Publication Date

2018

Abstract

In 2016, during a major Zika virus (ZIKV) outbreak in Maracaibo, Venezuela, a 49-year-old woman and an unrelated 4-year-old boy developed bilateral optic neuritis 2–3 weeks after presenting an acute febrile illness characterized by low-grade fever, rash and myalgia [1]. Both patients presented sudden, painless bilateral loss of vision with no corneal or uveal abnormalities. Fundoscopic examination revealed oedema of the optic nerve and optic disc pallor. Optical coherence tomography confirmed bilateral optic nerve head swelling in the case of the adult, but it was not carried out in the child. Automated perimetry performed in the adult revealed bilateral diffuse visual field loss. Magnetic resonance imaging of the brain in both cases was unremarkable. Both patients were diagnosed with bilateral optic neuritis of possible infectious or parainfectious origin. Differential diagnoses that were considered and subsequently discarded included arteritic and non-arteritic ischaemic optic neuropathy, and brain disorders such as multiple sclerosis and brain tumours. Both patients were seropositive for anti-ZIKV IgG and seronegative for anti-ZIKV IgM. In addition, both patients were positive for anti-dengue virus (DENV) IgG for all four DENV serotypes. Management included intravenous methylprednisolone for 3 days, followed by oral prednisolone for 11 days. Although the patients presented a modest improvement in their vision, they continued to have visual impairment after several months of follow-up [1].

Comments

Copyright 2018 The Authors

Recommended Citation

Zaidi, M. B., De Moraes, C. G., Petitto, M., Yepez, J. B., Sakuntabhai, A., Simon-Loriere, E., Prot, M., Ruffie, C., Kim, S. S., Allikmets, R., Terwilliger, J. D., Lee, J. H., & Maestre, G. E. (2018). Non-congenital severe ocular complications of Zika virus infection. JMM case reports, 5(6), e005152. https://doi.org/10.1099/jmmcr.0.005152

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Title

JMM Case Rep

DOI

10.1099/jmmcr.0.005152

Academic Level

faculty

Mentor/PI Department

Neuroscience