School of Medicine Publications and Presentations

Lipidomics in the Study of Hypertension in Metabolic Syndrome

Document Type

Article

Publication Date

2-6-2017

Abstract

Purpose of Review

The entire gamut of changes in the lipid profile that precede, predict, and correlate with hypertension in metabolic syndrome is unknown.

Recent Findings

The power, resolution, and accuracy of lipidomic assay technologies have brought us to the threshold of another information explosion. Understanding of hypertension and its pathophysiology especially within the setting of metabolic syndrome has been greatly improved by recent lipidomic studies. Hypertension in metabolic syndrome differs from other forms of hypertension, and recent studies have highlighted this difference in many interesting ways. Mounting evidence points towards a derangement of the sphingolipid pathway that may trigger the precursor clinical conditions of hypertension as well as hypertension itself. In this review, we summarize the available published literature in this field and propose a unifying hypothesis based on the published evidence.

Summary

Recent studies have created substantial interest and advances in the understanding of hypertension in metabolic syndrome. Studies that directly test these concepts within a lipidomic framework are urgently needed.

Comments

Copyright © 2017, Springer Science Business Media New York

https://rdcu.be/cZD7c

Publication Title

Curr Hypertens Rep

DOI

10.1007/s11906-017-0705-6

Academic Level

faculty

Mentor/PI Department

Office of Human Genetics

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