Data on genetic associations of carotid atherosclerosis markers in Mexican American and European American rheumatoid arthritis subjects

Authors

Rector Arya, The University of Texas Rio Grande Valley
Agustin Escalante
Vidya S. Farook, The University of Texas Rio Grande Valley
Jose F. Restrepo
Daniel F. Battafarano
Marcio Almeida, The University of Texas Rio Grande Valley
Mark Kos, The University of Texas Rio Grande Valley
Marcel Fourcaudot
Srinivas Mummidi, The University of Texas Rio Grande Valley
Satish Kumar, The University of Texas Rio Grande Valley
Joanne E. Curran, The University of Texas Rio Grande Valley
Christopher Jenkinson, The University of Texas Rio Grande Valley
John Blangero, The University of Texas Rio Grande Valley
Ravi Duggirala, The University of Texas Rio Grande Valley
Inmaculada Del Rincon

Document Type

Article

Publication Date

2-2018

Abstract

Carotid Intima-media thickness (CIMT) and plaque are well established markers of subclinical atherosclerosis and are widely used for identifying subclinical atherosclerotic disease. We performed association analyses using Metabochip array to identify genetic variants that influence variation in CIMT and plaque, measured using B-mode ultrasonography, in rheumatoid arthritis (RA) patients. Data on genetic associations of common variants associated with both CIMT and plaque in RA subjects involving Mexican Americans (MA) and European Americans (EA) populations are presented in this article. Strong associations were observed after adjusting for covariate effects including baseline clinical characteristics and statin use. Susceptibility loci and genes and/or nearest genes associated with CIMT in MAs and EAs with RA are presented. In addition, common susceptibility loci influencing CIMT and plaque in both MAs and EAs have been presented. Polygenic Risk Score (PRS) plots showing complementary evidence for the observed CIMT and plaque association signals are also shown in this article. For further interpretation and details, please see the research article titled "A Genetic Association Study of Carotid Intima-Media Thickness (CIMT) and Plaque in Mexican Americans and European Americans with Rheumatoid Arthritis" which is being published in Atherosclerosis (Arya et al., 2018) [1].(Arya et al., in press) Thus, common variants in several genes exhibited significant associations with CIMT and plaque in both MAs and EAs as presented in this article. These findings may help understand the genetic architecture of subclinical atherosclerosis in RA populations.

Comments

© 2018 The Authors. Published by Elsevier Inc.

Recommended Citation

Arya, R., Escalante, A., Farook, V. S., Restrepo, J. F., Battafarano, D. F., Almeida, M., Kos, M. Z., Fourcaudot, M. J., Mummidi, S., Kumar, S., Curran, J. E., Jenkinson, C. P., Blangero, J., Duggirala, R., & Del Rincon, I. (2018). Data on genetic associations of carotid atherosclerosis markers in Mexican American and European American rheumatoid arthritis subjects. Data in brief, 17, 820–829. https://doi.org/10.1016/j.dib.2018.02.006

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Title

Data in Brief

DOI

10.1016/j.dib.2018.02.006

Academic Level

faculty

Mentor/PI Department

Office of Human Genetics