School of Medicine Publications and Presentations
Document Type
Conference Proceeding
Publication Date
9-17-2018
Abstract
We conducted a genome-wide linkage scan to detect loci that influence the levels of fasting triglycerides in plasma. Fasting triglyceride levels were available at 4 time points (visits), 2 pre- and 2 post-fenofibrate intervention. Multipoint identity-by-descent (MIBD) matrices were derived from genotypes using IBDLD. Variance-component linkage analyses were then conducted using SOLAR (Sequential Oligogenic Linkage Analysis Routines). We found evidence of linkage (logarithm of odds [LOD] ≥3) at 5 chromosomal regions with triglyceride levels in plasma. The highest LOD scores were observed for linkage to the estimated genetic value (additive genetic component) of the log-normalized triglyceride levels in plasma. Our results suggest that a chromosome 10 locus at 37 cM (LODpre = 3.01, LODpost = 3.72) influences fasting triglyceride levels in plasma regardless of the fenofibrate intervention, and that loci in chromosomes 1 at 170 cM and 4 at 24 cM ceases to affect the triglyceride levels when fenofibrate is present, while the regions in chromosomes 6 at 136 to 162 cM and 11 at 39 to 40 cM appear to influence triglyceride levels in response to fenofibrate.
Recommended Citation
Peralta, J.M., Blackburn, N.B., Porto, A. et al. Genome-wide linkage scan for loci influencing plasma triglyceride levels. BMC Proc 12 (Suppl 9), 52 (2018). https://doi.org/10.1186/s12919-018-0137-6
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
BMC Proceedings
DOI
10.1186/s12919-018-0137-6
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
Copyright © 2018, The Author(s).