School of Medicine Publications and Presentations
Document Type
Article
Publication Date
8-2019
Abstract
Over the past decade, there has been a change in the epidemiology of oral cavity squamous cell cancer (OC-SCC). Many new cases of OC-SCC lack the recognized risk factors of smoking, alcohol and human papilloma virus. The aim of this study was to determine if the oral microbiome may be associated with OC-SCC in nonsmoking HPV negative patients. We compared the oral microbiome of HPV-negative nonsmoker OC-SCC(n = 18), premalignant lesions(PML) (n = 8) and normal control patients (n = 12). Their oral microbiome was sampled by oral wash and defined by 16S rRNA gene sequencing. We report that the periodontal pathogens Fusobacterium, Prevotella, Alloprevotella were enriched while commensal Streptococcus depleted in OC-SCC. Based on the four genera plus a marker genus Veillonella for PML, we classified the oral microbiome into two types. Gene/pathway analysis revealed a progressive increase of genes encoding HSP90 and ligands for TLRs 1, 2 and 4 along the controls→PML → OC-SCC progression sequence. Our findings suggest an association between periodontal pathogens and OC-SCC in non smoking HPV negative patients.
Recommended Citation
Ganly, I., Yang, L., Giese, R. A., Hao, Y., Nossa, C. W., Morris, L. G. T., Rosenthal, M., Migliacci, J., Kelly, D., Tseng, W., Hu, J., Li, H., Brown, S., & Pei, Z. (2019). Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus. International journal of cancer, 145(3), 775–784. https://doi.org/10.1002/ijc.32152
Publication Title
International journal of cancer
DOI
10.1002/ijc.32152
Academic Level
faculty
Comments
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