Cystic fibrosis-related diabetes: The unmet need

Authors

Leonardo Pozo, The University of Texas Rio Grande Valley
Fatimah Bello, The University of Texas Rio Grande Valley
Yamely Mendez
Salim Surani

Document Type

Article

Publication Date

6-2020

Abstract

Cystic fibrosis (CF) is a common autosomal recessive disease. Life expectancy of patients with CF continues to improve mainly driven by the evolving therapies for CF-related organ dysfunction. The prevalence of CF-related diabetes (CFRD) increases exponentially as patients’ age. Clinical care guidelines for CFRD from 2010, recommend insulin as the mainstay of treatment. Many patients with CFRD may not require exogenous insulin due to the heterogeneity of this clinical entity. Maintenance of euglycemia by enhancing endogenous insulin production, secretion and degradation with novel pharmacological therapies like glucagonlike peptide-1 agonist is an option that remains to be fully explored. As such, the scope of this article will focus on our perspective of glucagon-like peptide-1 receptor agonist in the context of CFRD. Other potential options such as sodiumglucose cotransporter-2 and dipeptidyl peptidase 4 inhibitors and their impact on this patient population is limited and further studies are required.

Comments

Original published version available at https://dx.doi.org/10.4239/wjd.v11.i6.213

Recommended Citation

Pozo, L., Bello, F., Mendez, Y., & Surani, S. (2020). Cystic fibrosis-related diabetes: The unmet need. World Journal of Diabetes, 11(6), 213–217. https://doi.org/10.4239/wjd.v11.i6.213

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

First Page

213

Last Page

217

Publication Title

World Journal of Diabetes

DOI

10.4239/wjd.v11.i6.213

Academic Level

faculty

Mentor/PI Department

Internal Medicine