Metabolic regulation in HPV associated head and neck squamous cell carcinoma

Authors

Vaishali Chandel
Sibi Raj
Prabhat Kumar
Shilpi Gupta
Anupam Dhasmana, The University of Texas Rio Grande ValleyFollow
Kavindra Kumar Kesari
Janne Ruokolainen
Pravesh Mehra
Bhudev C. Das
Mohammad Amjad Kamal
Dhruv Kumar

Document Type

Article

Publication Date

10-2020

Abstract

Cancer cells exhibit distinct energy metabolic pathways due to multiple oncogenic events. In normoxia condition, the anaerobic glycolysis (Warburg effect) is highly observed in head and neck squamous cell carcinoma (HNSCC). HNSCC is associated with smoking, chewing tobacco, consumption of alcohol or Human Papillomavirus (HPV) infection primarily HPV16. In recent years, the correlation of HPV with HNSCC has significantly expanded. Despite the recent advancement in therapeutic approaches, the rate of HPV infected HNSCC has significantly increased in the last few years, specifically, in lower middle-income countries. The oncoproteins of High-risk Human Papillomavirus (HR-HPV), E6 and E7, alter the metabolic phenotype in HNSCC, which is distinct from non-HPV associated HNSCC. These oncoproteins, modulate the cell cycle and metabolic signalling through interacting with tumor suppressor proteins, p53 and pRb. Since, metabolic alteration represents a major hallmark for tumorigenesis, HPV acts as a source of biomarker linked to cancer progression in HNSCC. The dependency of cancer cells to specific nutrients and alteration of various metabolic associated genes may provide a unique opportunity for pharmacological intervention in HPV infected HNSCC. In this review, we have discussed the molecular mechanism (s) and metabolic regulation in HNSCC depending on the HPV status. We have also discussed the possible potential therapeutic approaches for HPV associated HNSCC through targeting metabolic pathways.

Comments

Original published version available at https://doi.org/10.1016/j.lfs.2020.118236

Recommended Citation

Chandel, V., Raj, S., Kumar, P., Gupta, S., Dhasmana, A., Kesari, K. K., Ruokolainen, J., Mehra, P., Das, B. C., Kamal, M. A., & Kumar, D. (2020). Metabolic regulation in HPV associated head and neck squamous cell carcinoma. Life sciences, 258, 118236. https://doi.org/10.1016/j.lfs.2020.118236

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Publication Title

Life sciences

DOI

10.1016/j.lfs.2020.118236

Academic Level

faculty

Mentor/PI Department

Immunology and Microbiology