School of Medicine Publications and Presentations
Document Type
Article
Publication Date
1-2020
Abstract
Prostate cancer (PCa) cells exploit the aberrant lipid signaling and metabolism as their survival advantage. Also, intracellular storage lipids act as fuel for the PCa proliferation. However, few studies were available that addressed the topic of targeting lipid metabolism in PCa. Here, we assessed the tannic acid (TA) lipid-targeting ability and its capability to induce endoplasmic reticulum (ER) stress by reactive oxygen species (ROS) in PCa cells. TA exhibited dual effects by inhibiting lipogenic signaling and suppression of lipid metabolic pathways. The expression of proteins responsible for lipogenesis was down regulated. The membrane permeability and functionality of PCa were severely affected and caused nuclear disorganization during drug exposure. Finally, these consolidated events shifted the cell’s survival balance towards apoptosis. These results suggest that TA distinctly interferes with the lipid signaling and metabolism of PCa cells.
Recommended Citation
Nagesh, P.K.B., Chowdhury, P., Hatami, E. et al. Tannic acid inhibits lipid metabolism and induce ROS in prostate cancer cells. Sci Rep 10, 980 (2020). https://doi.org/10.1038/s41598-020-57932-9
Publication Title
Scientific Reports
DOI
10.1038/s41598-020-57932-9
Academic Level
faculty
Mentor/PI Department
Immunology and Microbiology
Comments
© The Author(s) 2020. Original published version available at https://doi.org/10.1038/s41598-020-57932-9