Posters
Presentation Type
Poster
Discipline Track
Biomedical Science
Abstract Type
Research/Clinical
Abstract
Background: Alzheimer's disease (AD) is one of the most common neurodegenerative disorders that has been associated with a strong genetic component. In addition, AD is often comorbid with neuropsychiatric conditions, some of which are early indicators of the disease. Specific demographic factors and genetic variants have been identified as risks in non-Hispanic populations; however, there are limited studies observed on the Hispanic population. Therefore, in our current study, we focused on investigating a known gene, APOE, that is associated with AD-related phenotypes and two psychiatric diseases (depression and anxiety) within the U.S. Hispanic population.
Methods: A total of 1,382 subjects were collected from the Texas Alzheimer's Research and Care Consortium (TARCC, N=1,320) and the Initial Study of Longevity and Dementia from the Rio Grande Valley (ISLD-RGV, N=62). Questionnaires for demographics, lifestyle, medical history, and blood/saliva samples were collected. We genotyped for the APOE gene based on two single nucleotide polymorphisms. Statistical analysis was performed using Chi-square tests, independent samples t-tests and multivariable logistic regression models using SPSS version 26.
Results: Current finding indicated that APOE-ε4 was associated with not only AD (p<0.0001), but also anxiety (p<0.0001) and depression (p=0.0004). However, APOE-ε3 was associated with depression (p=0.002) in the Hispanic population. We provide additional evidence in which APOE-ε4 increased the risk for AD in Hispanics.
Conclusions: For the first time, APOE alleles show increased risks for anxiety and depression in Hispanics. However, further research is warranted to confirm the current findings regarding this population.
Academic/Professional Position
Community Partner
Recommended Citation
Gamez, Daniela; Guajardo, Erika; Galvan Gutierrez, Aida; Padilla, Victoria I.; Lozano, Stephanie; Gil, Mario; Maestre, Gladys E.; Wang, KeSheng; and Xu, Chun, "APOE gene associated with dementia related traits, depression and anxiety in the Hispanic population." (2024). Research Symposium. 57.
https://scholarworks.utrgv.edu/somrs/2023/posters/57
Included in
APOE gene associated with dementia related traits, depression and anxiety in the Hispanic population.
Background: Alzheimer's disease (AD) is one of the most common neurodegenerative disorders that has been associated with a strong genetic component. In addition, AD is often comorbid with neuropsychiatric conditions, some of which are early indicators of the disease. Specific demographic factors and genetic variants have been identified as risks in non-Hispanic populations; however, there are limited studies observed on the Hispanic population. Therefore, in our current study, we focused on investigating a known gene, APOE, that is associated with AD-related phenotypes and two psychiatric diseases (depression and anxiety) within the U.S. Hispanic population.
Methods: A total of 1,382 subjects were collected from the Texas Alzheimer's Research and Care Consortium (TARCC, N=1,320) and the Initial Study of Longevity and Dementia from the Rio Grande Valley (ISLD-RGV, N=62). Questionnaires for demographics, lifestyle, medical history, and blood/saliva samples were collected. We genotyped for the APOE gene based on two single nucleotide polymorphisms. Statistical analysis was performed using Chi-square tests, independent samples t-tests and multivariable logistic regression models using SPSS version 26.
Results: Current finding indicated that APOE-ε4 was associated with not only AD (p<0.0001), but also anxiety (p<0.0001) and depression (p=0.0004). However, APOE-ε3 was associated with depression (p=0.002) in the Hispanic population. We provide additional evidence in which APOE-ε4 increased the risk for AD in Hispanics.
Conclusions: For the first time, APOE alleles show increased risks for anxiety and depression in Hispanics. However, further research is warranted to confirm the current findings regarding this population.