Posters
Presentation Type
Poster
Discipline Track
Biomedical Science
Abstract Type
Research/Clinical
Abstract
Background: Reactive oxygen species (ROS) play a dual role in biomedicine, acting as essential molecules in cellular metabolism and signaling while posing a threat to cellular components through oxidative damage. This poster explores the significance of ROS in various physiological processes and hematological diseases associated with cardiovascular disease and cerebrovascular disease.
Methods: We have thoroughly studied over 60 most recent or related literature to the topic and determine important roles of ROS in various biological systems, cardiovascular and cerebrovascular diseases.
Results: ROS are crucial in cell signaling, immune response, and gene expression, but excessive levels can lead to oxidative stress and cellular dysfunction. Oxidative stress can disrupt intracellular processes, including programmed cell death, downstream signaling, and cellular proliferation. Consequently, the regular functioning of tissues subject to oxidative stress is altered, enabling the development of diseases. ROS play a significant role in the pathogenesis of coronary heart disease, contributing to atherosclerosis, endothelial dysfunction, and thrombosis. ROS production leads to modification of LDL, causing atherosclerotic plaques. Increased ROS production in vascular smooth muscle cells and impaired endothelial function promote atherosclerosis development. Additionally, high glucose levels promote the formation of platelet-monocyte aggregates in diabetic patients, increasing risk of coronary artery disease. ROS also play a critical role in pathogenesis of cerebral vascular disease (CeVD). Oxidative stress markers have been correlated with severity of CeVD, including stroke and cognitive impairment. Potential therapeutic strategies, including polyphenols and ROS scavengers, are effective in mitigating oxidative stress-related damage and improving outcomes in CeVD patients.
Conclusion: This understanding of ROS in biomedicine guides innovative therapies to restore redox balance and reduce oxidative stress's detrimental effects.
Academic/Professional Position
Medical Student
Recommended Citation
Zuo, Alex; Trejo, Hector; and Alanis, A., "The Significance of Reactive Oxygen Species in Physiological Processes and Hematological Disorders: Insights into Cardiovascular and Cerebrovascular Diseases" (2024). Research Symposium. 61.
https://scholarworks.utrgv.edu/somrs/2023/posters/61
Included in
The Significance of Reactive Oxygen Species in Physiological Processes and Hematological Disorders: Insights into Cardiovascular and Cerebrovascular Diseases
Background: Reactive oxygen species (ROS) play a dual role in biomedicine, acting as essential molecules in cellular metabolism and signaling while posing a threat to cellular components through oxidative damage. This poster explores the significance of ROS in various physiological processes and hematological diseases associated with cardiovascular disease and cerebrovascular disease.
Methods: We have thoroughly studied over 60 most recent or related literature to the topic and determine important roles of ROS in various biological systems, cardiovascular and cerebrovascular diseases.
Results: ROS are crucial in cell signaling, immune response, and gene expression, but excessive levels can lead to oxidative stress and cellular dysfunction. Oxidative stress can disrupt intracellular processes, including programmed cell death, downstream signaling, and cellular proliferation. Consequently, the regular functioning of tissues subject to oxidative stress is altered, enabling the development of diseases. ROS play a significant role in the pathogenesis of coronary heart disease, contributing to atherosclerosis, endothelial dysfunction, and thrombosis. ROS production leads to modification of LDL, causing atherosclerotic plaques. Increased ROS production in vascular smooth muscle cells and impaired endothelial function promote atherosclerosis development. Additionally, high glucose levels promote the formation of platelet-monocyte aggregates in diabetic patients, increasing risk of coronary artery disease. ROS also play a critical role in pathogenesis of cerebral vascular disease (CeVD). Oxidative stress markers have been correlated with severity of CeVD, including stroke and cognitive impairment. Potential therapeutic strategies, including polyphenols and ROS scavengers, are effective in mitigating oxidative stress-related damage and improving outcomes in CeVD patients.
Conclusion: This understanding of ROS in biomedicine guides innovative therapies to restore redox balance and reduce oxidative stress's detrimental effects.