Posters
Presentation Type
Poster
Discipline Track
Biomedical Science
Abstract Type
Research/Clinical
Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment, memory loss, and disturbances in behavior. The exact cause of the disease is unknown but there is evidence of molecular pathways alteration within the brain. Many molecular mechanisms have been studied for the progression of AD. Nonetheless, the contribution of the signal transducer and activator of transcription 1 (STAT1) and interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) genes have not been well established in AD pathology. This study aimed to investigate the contribution of STAT1 and IFIT3 in the BALB/C and APP/PS1 mouse models. We analyzed the STAT1 and IFIT3 gene expression through RT-PCR and protein expression using immunohistochemistry in BALB/C and APP/PS1 mouse models. We found that the expression of STAT1 and IFIT3 genes was significantly higher in APP/PS1 mice compared to the wild type-mice, indicating that these two genes were involved in the pathogenesis of AD. Our results suggest that STAT1 and IFIT3 genes may be useful therapeutic targets for the early diagnosis and treatment of AD.
Recommended Citation
Das, Ranjit Kumar; Sahoo, Nirakar; Xu, Chun; Rodrigo, Hansapani; Murphy, Michael Paul; Roy, Upal; and Roy, Deepa, "Alteration of the Interferon alpha signaling pathway significantly affects Alzheimer's Disease Pathology in APP/PS1 mouse model." (2024). Research Symposium. 7.
https://scholarworks.utrgv.edu/somrs/2024/posters/7
Alteration of the Interferon alpha signaling pathway significantly affects Alzheimer's Disease Pathology in APP/PS1 mouse model.
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment, memory loss, and disturbances in behavior. The exact cause of the disease is unknown but there is evidence of molecular pathways alteration within the brain. Many molecular mechanisms have been studied for the progression of AD. Nonetheless, the contribution of the signal transducer and activator of transcription 1 (STAT1) and interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) genes have not been well established in AD pathology. This study aimed to investigate the contribution of STAT1 and IFIT3 in the BALB/C and APP/PS1 mouse models. We analyzed the STAT1 and IFIT3 gene expression through RT-PCR and protein expression using immunohistochemistry in BALB/C and APP/PS1 mouse models. We found that the expression of STAT1 and IFIT3 genes was significantly higher in APP/PS1 mice compared to the wild type-mice, indicating that these two genes were involved in the pathogenesis of AD. Our results suggest that STAT1 and IFIT3 genes may be useful therapeutic targets for the early diagnosis and treatment of AD.