Posters
Genetic Polymorphisms in PARK2-Exons Are Associated With Colorectal Cancer Risk in North Indian Population
Presentation Type
Poster
Discipline Track
Biomedical Science
Abstract Type
Research/Clinical
Abstract
Background: Single nucleotide polymorphism (SNP) is the most abundant form of genetic variation among individuals. In various studies, it is found that the association of SNP in exonic regions of PARK2 causes the promotion of metabolic disorders like cancer. Globally, colorectal cancer is the most prevalent cancer type in both men and women. The association of SNPs in the development and recurrence of colorectal cancer in the North Indian Population has remained elusive. However, in the present study, we assessed the association between rs1801334 G1281A (Asp394 Asn) & rs1801474 G601A (Ser167Asn) polymorphisms and colorectal cancer (CRC) incidences among the North Indian population.
Methods: In order to analyze the association of these polymorphisms with the risk of colorectal cancer, we genotyped 200 unrelated subjects (100 patients and 100 healthy controls). For this genomic DNA is isolated by using venous blood & SNPs were genotyped by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism method.
Results: We observed that the Allele and genotype frequencies for the 2 polymorphisms in the PARK2 is differ between colorectal cancer patients and controls.
Conclusions: Our finding, concludes that the genetic variation at the exonic regions of the PARK2 gene did contribute to the risk of developing colorectal cancer in the North Indian population. Therefore, in this study polymorphisms in the exonic region of the PARK2 gene could be useful to investigate the association with other cancer types in which parkin could be involved
Academic/Professional Position
Graduate Student
Recommended Citation
Kumari, Rashmi; Rani, M.; Siddiqui, A.; Nigam, A.; and Rizvi, M. M. A., "Genetic Polymorphisms in PARK2-Exons Are Associated With Colorectal Cancer Risk in North Indian Population" (2023). Research Symposium. 117.
https://scholarworks.utrgv.edu/somrs/theme1/posters/117
Genetic Polymorphisms in PARK2-Exons Are Associated With Colorectal Cancer Risk in North Indian Population
Background: Single nucleotide polymorphism (SNP) is the most abundant form of genetic variation among individuals. In various studies, it is found that the association of SNP in exonic regions of PARK2 causes the promotion of metabolic disorders like cancer. Globally, colorectal cancer is the most prevalent cancer type in both men and women. The association of SNPs in the development and recurrence of colorectal cancer in the North Indian Population has remained elusive. However, in the present study, we assessed the association between rs1801334 G1281A (Asp394 Asn) & rs1801474 G601A (Ser167Asn) polymorphisms and colorectal cancer (CRC) incidences among the North Indian population.
Methods: In order to analyze the association of these polymorphisms with the risk of colorectal cancer, we genotyped 200 unrelated subjects (100 patients and 100 healthy controls). For this genomic DNA is isolated by using venous blood & SNPs were genotyped by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism method.
Results: We observed that the Allele and genotype frequencies for the 2 polymorphisms in the PARK2 is differ between colorectal cancer patients and controls.
Conclusions: Our finding, concludes that the genetic variation at the exonic regions of the PARK2 gene did contribute to the risk of developing colorectal cancer in the North Indian population. Therefore, in this study polymorphisms in the exonic region of the PARK2 gene could be useful to investigate the association with other cancer types in which parkin could be involved