Posters
Serum profiling of inflammatory cytokines and obesity and stress-associated hormones in women with or without breast cancer
Presentation Type
Poster
Discipline Track
Clinical Science
Abstract Type
Research/Clinical
Abstract
Background: Breast cancer (BC)health disparities exist between African American (AA)and Caucasian American (CA) women. AA women develop BC earlier in life and are diagnosed with more aggressive phenotype leading to a poorer prognosis than their CA counterparts. Several factors, ranging from social, economic, behavioral to inherent biological differences, are associated with disparities and often one factor influences the other. Here we examined the levels of stress (cortisol),obesity (leptin) hormones and inflammatory cytokines (resistin and IL6) in serum samples obtained from AA and CA women with or without BC.
Methods: AA and CA women who visited University of South Alabama Health Hospitals, were asked to participate in this study voluntarily and their consent was obtained. Blood samples were collected from a total of 30 women without BC (15 AA and 15 CA) and 44 with a BC diagnosis (22 AA and 22 CA). Serum was isolated by centrifugation after coagulation, aliquoted and stored at −80 °C. Serum levels of resistin, IL-6, leptin, and cortisol were quantified by performing Enzyme linked Immunosorbent assay using commercial kits. Statistical analyses were performed using Graph pad prism 8.0.
Results: High levels of serum cortisol, leptin, resistin and IL-6 were observed in BC patients. Furthermore, AA women with or without BC diagnosis showed significantly higher levels of these hormones and cytokines than CA women.
Conclusion: Higher levels of cortisol, leptin, resistin and IL-6 in BC patients suggest their role in aggressive tumor phenotypes, immune suppression and consequently poorer prognosis of the patients.
Academic/Professional Position
Faculty
Academic/Professional Position (Other)
PhD
Recommended Citation
Sudan, Sarabjeet Kour; Deshmukh, Sachin Kumar; Poosarla, Teja; Akbar, Shalla; Holliday, Nicolette P.; Dyess, Donna Lynn; Singh, Ajay P.; and Singh, S., "Serum profiling of inflammatory cytokines and obesity and stress-associated hormones in women with or without breast cancer" (2023). Research Symposium. 119.
https://scholarworks.utrgv.edu/somrs/theme1/posters/119
Serum profiling of inflammatory cytokines and obesity and stress-associated hormones in women with or without breast cancer
Background: Breast cancer (BC)health disparities exist between African American (AA)and Caucasian American (CA) women. AA women develop BC earlier in life and are diagnosed with more aggressive phenotype leading to a poorer prognosis than their CA counterparts. Several factors, ranging from social, economic, behavioral to inherent biological differences, are associated with disparities and often one factor influences the other. Here we examined the levels of stress (cortisol),obesity (leptin) hormones and inflammatory cytokines (resistin and IL6) in serum samples obtained from AA and CA women with or without BC.
Methods: AA and CA women who visited University of South Alabama Health Hospitals, were asked to participate in this study voluntarily and their consent was obtained. Blood samples were collected from a total of 30 women without BC (15 AA and 15 CA) and 44 with a BC diagnosis (22 AA and 22 CA). Serum was isolated by centrifugation after coagulation, aliquoted and stored at −80 °C. Serum levels of resistin, IL-6, leptin, and cortisol were quantified by performing Enzyme linked Immunosorbent assay using commercial kits. Statistical analyses were performed using Graph pad prism 8.0.
Results: High levels of serum cortisol, leptin, resistin and IL-6 were observed in BC patients. Furthermore, AA women with or without BC diagnosis showed significantly higher levels of these hormones and cytokines than CA women.
Conclusion: Higher levels of cortisol, leptin, resistin and IL-6 in BC patients suggest their role in aggressive tumor phenotypes, immune suppression and consequently poorer prognosis of the patients.