Posters

Presentation Title

Treatment of Prostate Cancer by the Interaction of α-Peltatin with Tubulin Receptor

Presenting Author

Satyendra Singh

Presentation Type

Poster

Discipline Track

Patient Care

Abstract Type

Research/Clinical

Abstract

Prostate Cancer is the most common cancer of today’s era that damages the excretory system as well as reproductive power of human beings very badly. Since I’m likely to encounter these problems by inhibiting the dynamics of tubulin receptors of the human body by its interaction with α-Peltatin that may be useful for the treatment of prostate cancer and possibly other diseases like heart failure, and muscular dystrophy. α-Peltatin is a herbal therapy medication obtained from the dried rhizome and roots of Podophyllum peltatum when applied typically, it is a strong irritant to the skin and mucous membranes and can lead to poisoning because of systemic absorption and hence used to treat a vast variety of cancers through high-throughput screening. And also to highlight the gaps in our knowledge and explore future research needs. It includes pancreatic cancer, breast cancer, lung cancer, brain cancer, etc. This treatment is administered to the patient through intravenous injections. Optical ultracentrifuge studies of α-Peltatin treated tubulin show a small reduction in 25-S to 30-S peaks at 0°C. In electron microscopic studies the ring structure of tubulin is seen at 0°C but disappears if the temperature of tubulin incubated with α-Peltatin is raised to body temperature. α-Peltatin repels the replication of chromatin reticulum in mitosis thereby inhibiting the fastgrowing cancerous cells of the body for current as well as for future generations. Here I’m using Firefly software through the EHT method to get an accurate result in short time intervals. Interaction of α-Peltatin with the Tubulin promotes receptor-independent activation of G-proteins (also called Guanine Nucleotide-Binding proteins that act as a molecular switch inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior) which helps in modifying cell morphology for the treatment of such cancerous cells. The interaction studies discussed in this research paper will also be a boon for treating the problems caused by the SARS COVID-19 virus also in the incoming periods. Antimitotic drugs such as the α-Peltatin and some other antimitotic natural products show a promising result in prostate cancer therapy. However, the toxicity of these drugs as well as acquired drug resistance allows for an opportunity to develop agents with increase tolerability and specificity to the body cells. My investigation has opened the pathways of cancer cell resistance to antimitotic drugs that will result in the subsequent identification of novel biomarkers for future chemotherapy possessing increased efficacy in an innovative way for today’s such cancer therapy.

Academic/Professional Position

Faculty

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Treatment of Prostate Cancer by the Interaction of α-Peltatin with Tubulin Receptor

Prostate Cancer is the most common cancer of today’s era that damages the excretory system as well as reproductive power of human beings very badly. Since I’m likely to encounter these problems by inhibiting the dynamics of tubulin receptors of the human body by its interaction with α-Peltatin that may be useful for the treatment of prostate cancer and possibly other diseases like heart failure, and muscular dystrophy. α-Peltatin is a herbal therapy medication obtained from the dried rhizome and roots of Podophyllum peltatum when applied typically, it is a strong irritant to the skin and mucous membranes and can lead to poisoning because of systemic absorption and hence used to treat a vast variety of cancers through high-throughput screening. And also to highlight the gaps in our knowledge and explore future research needs. It includes pancreatic cancer, breast cancer, lung cancer, brain cancer, etc. This treatment is administered to the patient through intravenous injections. Optical ultracentrifuge studies of α-Peltatin treated tubulin show a small reduction in 25-S to 30-S peaks at 0°C. In electron microscopic studies the ring structure of tubulin is seen at 0°C but disappears if the temperature of tubulin incubated with α-Peltatin is raised to body temperature. α-Peltatin repels the replication of chromatin reticulum in mitosis thereby inhibiting the fastgrowing cancerous cells of the body for current as well as for future generations. Here I’m using Firefly software through the EHT method to get an accurate result in short time intervals. Interaction of α-Peltatin with the Tubulin promotes receptor-independent activation of G-proteins (also called Guanine Nucleotide-Binding proteins that act as a molecular switch inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior) which helps in modifying cell morphology for the treatment of such cancerous cells. The interaction studies discussed in this research paper will also be a boon for treating the problems caused by the SARS COVID-19 virus also in the incoming periods. Antimitotic drugs such as the α-Peltatin and some other antimitotic natural products show a promising result in prostate cancer therapy. However, the toxicity of these drugs as well as acquired drug resistance allows for an opportunity to develop agents with increase tolerability and specificity to the body cells. My investigation has opened the pathways of cancer cell resistance to antimitotic drugs that will result in the subsequent identification of novel biomarkers for future chemotherapy possessing increased efficacy in an innovative way for today’s such cancer therapy.

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