Talks
Presentation Type
Oral Presentation
Discipline Track
Clinical Science
Abstract Type
Research/Clinical
Abstract
Background: To determine the association between Nutritional status of patient and the ability to complete all planned treatment in Head & Neck Squamous Cell Carcinoma(HNSCC).
Materials & Methods: This prospective cohort study was conducted at CRI India between 2018 and 2020. Patients diagnosed with HNSCC and planned for treatment were enrolled after written informed consent. Nutritional status was determined using- anthropometric measures and Subjective Global Assessment(SGA) scale before starting treatment. Patients were followed up for treatment details, complications and failure to complete planned treatment. Statistical analysis was performed using SPSS version 22. Data was analyzed using parametric and non-parametric tests, p value of 0.05 was considered significant.
Results: Total 161 patients were analyzed, mean age 56.3yr (±13.27 SD), 88.2% male, 64% cT3/4 stage, 91.9% ECOG PS 0 to 2. The age, gender, PS, subsite, stage, grade were not significantly associated with failure to complete planned treatment. Mean weight was 51.76 (±12.52 SD), 58.65 (±11.3 SD) kg (p=0.012), mean Body Mass Index(BMI) 19.36 (±4.3 SD), 21.92 (±4.09 SD) (p=0.009), median weight loss within 6months 11%, 3% (p=0.01), median SGA score 49, 38 (p=0.000) in patients who failed to complete treatment and who completed treatment. Percentage failure to complete treatment was 20%, 10.34% patients with weight ≤50kg, >50kg (p=0.12, RR=2.17); 28.95%, 8.2% with BMI21cm (p=0.008, RR=5.2), 7.06%, 19.74% with SGA score
Conclusions: Nutritional parameters like weight, BMI, MUAC, weight loss in 6 months, and SGA score are significantly associated with failure to complete treatment. Disparities in nutritional status of patients undergoing treatment for HNSCC need to be acknowledged.
Recommended Citation
Arora, Anshika and Saini, Sunil Kumar, "Association of Nutritional Status with Failure to Complete Planned Treatment in patients with HNSCC- a prospective cohort study in a Tertiary cancer centre in Northern India." (2023). Research Symposium. 5.
https://scholarworks.utrgv.edu/somrs/theme1/track1/5
Included in
Association of Nutritional Status with Failure to Complete Planned Treatment in patients with HNSCC- a prospective cohort study in a Tertiary cancer centre in Northern India.
Background: To determine the association between Nutritional status of patient and the ability to complete all planned treatment in Head & Neck Squamous Cell Carcinoma(HNSCC).
Materials & Methods: This prospective cohort study was conducted at CRI India between 2018 and 2020. Patients diagnosed with HNSCC and planned for treatment were enrolled after written informed consent. Nutritional status was determined using- anthropometric measures and Subjective Global Assessment(SGA) scale before starting treatment. Patients were followed up for treatment details, complications and failure to complete planned treatment. Statistical analysis was performed using SPSS version 22. Data was analyzed using parametric and non-parametric tests, p value of 0.05 was considered significant.
Results: Total 161 patients were analyzed, mean age 56.3yr (±13.27 SD), 88.2% male, 64% cT3/4 stage, 91.9% ECOG PS 0 to 2. The age, gender, PS, subsite, stage, grade were not significantly associated with failure to complete planned treatment. Mean weight was 51.76 (±12.52 SD), 58.65 (±11.3 SD) kg (p=0.012), mean Body Mass Index(BMI) 19.36 (±4.3 SD), 21.92 (±4.09 SD) (p=0.009), median weight loss within 6months 11%, 3% (p=0.01), median SGA score 49, 38 (p=0.000) in patients who failed to complete treatment and who completed treatment. Percentage failure to complete treatment was 20%, 10.34% patients with weight ≤50kg, >50kg (p=0.12, RR=2.17); 28.95%, 8.2% with BMI21cm (p=0.008, RR=5.2), 7.06%, 19.74% with SGA score
Conclusions: Nutritional parameters like weight, BMI, MUAC, weight loss in 6 months, and SGA score are significantly associated with failure to complete treatment. Disparities in nutritional status of patients undergoing treatment for HNSCC need to be acknowledged.