The Multiple Roles of 5-LO in Tissue Regeneration – Insights From Translational Animal Models Utilizing Pharmacological and Genetic Approaches

Authors

• Roel Navarro, The University of Texas Rio Grande Valley
• Nidhin John, The University of Texas Rio Grande ValleyFollow
• Claudia Biguetti, The University of Texas Rio Grande Valley

Document Type

Poster

Publication Date

4-2025

Abstract

Inflammation following tissue injury is a natural physiological response, where its course, duration, and intensity help determine whether it promotes beneficial or detrimental outcomes in tissue healing. Arachidonic acid (AA) serves as a substrate for5-lipoxygenase (5-LO) pathway, which synthesizes metabolites such as leukotrienes that influence both acute and chronic inflammatory response.  AA and its product's inhibitors are currently used to treat hypersensitivity reactions. However, literature suggests potential therapeutic efficacy in tissue healing.

Recommended Citation

Navarro, Roel; John, Nidhin; and Biguetti, Claudia, "The Multiple Roles of 5-LO in Tissue Regeneration – Insights From Translational Animal Models Utilizing Pharmacological and Genetic Approaches" (2025). School of Podiatric Medicine - Student Research. 46.
https://scholarworks.utrgv.edu/sopm_mspub/46