Document Type
Article
Publication Date
2-2017
Abstract
Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases. The study and interest in MMP has been fuelled by emerging evidence demonstrating the broad spectrum of molecules that can be cleaved by them and the myriad of biological processes that they can potentially regulate. The huge complexity of MMP functions within the ‘protease web’ is crucial for many physiologic and pathologic processes, including immunity, inflammation, bone resorption, and wound healing. Evidence points out that MMPs assemble in activation cascades and besides their classical extracellular matrix substrates, they cleave several signalling molecules—such as cytokines, chemokines, and growth factors, among others—regulating their biological functions and/or bioavailability during periodontal diseases. In this review, we provide an overview of emerging evidence of MMPs as regulators of periodontal inflammation.
Recommended Citation
Franco, C., Patricia, H. R., Timo, S., Claudia, B., & Marcela, H. (2017). Matrix Metalloproteinases as Regulators of Periodontal Inflammation. International journal of molecular sciences, 18(2), 440. https://doi.org/10.3390/ijms18020440
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Genes
Academic Level
faculty
DOI
https://doi.org/10.3390/ijms18020440
Comments
Copyright © 2017 by the authors.