School of Medicine Publications and Presentations
Document Type
Article
Publication Date
2020
Abstract
TG-interacting factor 1 (TGIF1) exerts inhibitory effects on transforming growth factor-beta (TGF-β) signaling by suppressing Smad signaling pathway at multiple levels. TGIF1 activity is important for normal embryogenesis and organogenesis, yet its dysregulation can culminate in tumorigenesis. For instance, increased expression of TGIF1 correlates with poor prognosis in triple-negative breast cancer patients, and enforced expression of TGIF1 facilitates Wnt-driven mammary tumorigenesis, suggesting that TGIF1 might function as an oncoprotein. Quite surprisingly, TGIF1 has recently been shown to function as a tumor suppressor in pancreatic ductal adenocarcinoma (PDAC), possibly owing to its ability to antagonize the pro-malignant transcription factor Twist1. In this article, we will briefly elaborate on the biological and clinical significance of the unique tumor-suppressive function of TGIF1 and its functional interaction with Twist1 in the context of PDAC pathogenesis and progression.
Recommended Citation
Razzaque, M. S., & Atfi, A. (2020). TGIF1-Twist1 axis in pancreatic ductal adenocarcinoma. Computational and Structural Biotechnology Journal, 18, 2568-2572. https://doi.org/10.1016/j.csbj.2020.09.023
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Publication Title
Computational and Structural Biotechnology Journal
DOI
https://doi.org/10.1016/j.csbj.2020.09.023
Academic Level
faculty
Mentor/PI Department
Medical Education
Comments
Copyright 2020 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license.