Document Type
Article
Publication Date
Winter 12-7-2025
Abstract
This comprehensive literature review synthesizes the most recent evidence and evolving clinical guidelines concerning percutaneous coronary intervention (PCI) from 2015 to 2025. The study integrates findings from 42 peer-reviewed trials, meta-analyses, registries, and international guideline statements issued by the American College of Cardiology/American Heart Association (ACC/AHA), European Society of Cardiology (ESC), and related societies. Results reveal a decade-long evolution in PCI practice marked by a shift from anatomy-driven to physiology and imaging-guided decision-making, supported by tools such as fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), intravascular ultrasound (IVUS), and optical coherence tomography (OCT). Modern guidelines emphasize individualized, team-based revascularization strategies integrating ischemic burden, anatomic complexity, and patient preference. Evidence from landmark trials including ISCHEMIA, COMPLETE, and FAME highlights the safety and clinical benefit of selective, physiology-validated PCI while reinforcing optimal medical therapy as first-line management in stable ischemic heart disease. Persistent controversies include the management of left main and multivessel disease, chronic total occlusions, revascularization timing in transcatheter aortic valve implantation (TAVI), and optimal duration of dual antiplatelet therapy (DAPT). Collectively, the literature underscores PCI’s transition into an era of precision revascularization, characterized by patient-specific assessment, evidence-based practice, and multidisciplinary collaboration. Continued research and harmonization of global guidelines will be essential to advance equitable, physiology-guided coronary care and improve long-term cardiovascular outcomes.
Recommended Citation
Alsabbagh, Bisher; Shala, Azeez; Rupert, Joshua; and Elsayed, Abdallah, "A Review of Recent and Developing Studies regarding Percutaneous Coronary Intervention (PCI): A Narrative Review" (2025). School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology). 452.
https://scholarworks.utrgv.edu/bio_fac/452
Creative Commons License
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Included in
Biology Commons, Cardiology Commons, Circulatory and Respiratory Physiology Commons, Internal Medicine Commons, Surgery Commons
