Polystyrenesulfonate-catalyzed synthesis of novel pyrroles through Paal-Knorr reaction

Authors

Mandira Banik, The University of Texas Rio Grande Valley
Bianca Ramirez, The University of Texas Rio Grande Valley
Ashwini Reddy, The University of Texas Rio Grande Valley
Debasish Bandyopadhyay, The University of Texas Rio Grande ValleyFollow
Bimal K. Banik, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

3-27-2012

Abstract

Background: The classical Paal-Knorr reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful pyrrole derivatives.

Results: Polystyrenesulfonate-catalyzed simple synthesis of substituted pyrroles following Paal-Knorr reaction has been accomplished with an excellent yield in aqueous solution. This method also produces pyrroles with multicyclic polyaromatic amines.

Conclusions: The present procedure for the synthesis of N-polyaromatic substituted pyrroles will find application in the synthesis of potent biologically active molecules.

Comments

© 2012 Banik et al; licensee Springer.

Recommended Citation

Banik, M., Ramirez, B., Reddy, A. et al. Polystyrenesulfonate-catalyzed synthesis of novel pyrroles through Paal-Knorr reaction. Org Med Chem Lett 2, 11 (2012). https://doi.org/10.1186/2191-2858-2-11

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

Publication Title

Organic and Medicinal Chemistry Letters

DOI

10.1186/2191-2858-2-11