The conjugate addition of amines to conjugated alkenes (commonly known as aza-Michael reaction) constitutes a key step for the synthesis of various complex natural products, antibiotics, α-amino alcohols and chiral auxiliaries. Ultrasound-induced addition of several amines to α, β-unsaturated ketones, esters and nitriles has been carried out very efficiently in water as well as under solvent-free conditions. No catalysts or solid supports have been used in this method. Remarkable enhancement of reaction rate has been observed in water under ultrasound-induced method. This environmentally benign procedure has provided clean formation of the products with better selectivity.
Bandyopadhyay, D., Mukherjee, S., Turrubiartes, L. C., & Banik, B. K. (2012). Ultrasound-assisted aza-Michael reaction in water: A green procedure. Ultrasonics Sonochemistry, 19(4), 969–973. https://doi.org/10.1016/j.ultsonch.2011.11.009
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