Date of Award
Master of Science (MS)
Biochemistry and Molecular Biology
Dr. Manish Tripathi
Dr. Bilal Hafeez
Dr. Murali Yallapu
Liver cancer is the fifth leading cause of mortality attributed to cancer. Among various histological types, hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer. There is a need to identify new biomarkers to help the physician, and allow them to decide what may be the most effective treatment for the patient. POTE-2 is one of the 14 paralogs apart of the ancestral POTE gene family. POTE-2 has been shown to be upregulated in non-small cell lung cancer and colorectal cancer, and is associated with increased migration, invasion, tumor size and poor survival. Evaluation of the Cancer Genome Atlas for POTE-2 in liver cancer showed increased expression in malignant vs tumor and expression correlated with increased stage and grade. This was further validated through a liver cDNA and tissue microarray. Gain of function studies showed increased phosphorylation of major kinases and increased cellular invasion. The findings indicate that POTE-2 expression is increased in cancer, is associated with advanced cancer, and could play a significant role in cancer progression.
Lopez, Samantha, "Role of POTE Ankyrin Domain Family Member 2 (POTE-2) in Liver Cancer" (2022). Theses and Dissertations. 1064.
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