Theses and Dissertations

Date of Award


Document Type


Degree Name

Master of Science (MS)


Biochemistry and Molecular Biology

First Advisor

Dr. Chun Xu

Second Advisor

Dr. Gladys Maestre

Third Advisor

Dr. Mario Gil


Diseases linked to high cholesterol have been well studied and several diseases-associated candidate genes have been suggested. Among these, the apolipoprotein E gene (APOE) gene associated with lipid metabolism and lipid-related traits was reported in the non-Hispanic population. There are three types of alleles APOE ε2, ε3, and ε4. The APOE ε4 allele has been identified as a biomarker for Alzheimer’s disease (AD) and cardiovascular disease (CVD). In recent years, there have been limited studies regarding the association between the APOE gene and hypercholesterolemia in the Mexican American population. Therefore, the aim of this study is to investigate the frequencies of the APOE alleles and study their relationship with cholesterol levels and lipid-related traits in the Mexican American population. For the first, we have demonstrated that APOE ε4 allele is associated with hypercholesterolemia in the Mexican American population. Further research is required to confirm the support of our current findings.


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