Theses and Dissertations
Date of Award
5-2022
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Dr. Shizue Mito
Second Advisor
Dr. Jose Gutierrez
Third Advisor
Dr. Yonghong Zhang
Abstract
In 2009 bioactive compounds from marine Streptomyces species was isolated which resulted in deriving four isoquinoline-quinone alkaloids known as Mansouramycins A-D. There have been reports that there are 36 non-small cancer cells against cytotoxicity in Mansouramycins A-C in lung cancer, breast cancer, melanoma, and prostate cancer cells. Reports that have conducted total syntheses were all specific to a single compound only Mansouramycin A and D. However, in precedent methods, to obtain the derivatives with different substituents are limited when the substituents are on the fused-pyridine ring. Thus, a develop a systematic synthetic methods of isoquinoline-quinones, which are to be able to obtain the natural Mansouramycins and their derivative by the usage of different amino acids via synthesis the aminoacetals.
Recommended Citation
Zepeda, Abigail M., "Total Synthesis of Mansouramycin A" (2022). Theses and Dissertations. 1079.
https://scholarworks.utrgv.edu/etd/1079
Comments
Copyright 2022 Abigail M. Zepeda. All Rights Reserved.
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