Fabrication and Characterization of Force Spun Polymeric Nanofiber for Drug Delivery and Tissue Engineering Applications

Author

Salahuddin Ahmed, The University of Texas Rio Grande Valley

Date of Award

12-2022

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Mechanical Engineering

First Advisor

Dr. Karen Lozano

Second Advisor

Dr. Robert Gilkerson

Third Advisor

Dr. Rogelio Benitez

Abstract

This study focuses on the development and characterization of polymeric nanofiber for drug delivery and tissue engineering applications. In this study, poly(lactic-co-glycolic) acid (PLGA), Poly-vinyl alcohol (PVA), and Pullulan(PL) were used as the base polymers to develop the nanofiber. Bioactive components Oleanolic acid(OA), Oxymatrine(OM), and Salvianolic Acid(SA) were incorporated in PLGA, PVA, and PL, respectively, via solution mixing. The nano fiber systems were developed using the Forcespinning® method. Morphological, thermo-physical, and biological properties of the fiber mats were analyzed. The composite fiber system containing OA showed a very high drug loading efficiency. The composite fiber system containing high concentration of OM(33%) and SA(20% and 33%) showed effective inhibition against the proliferation of HCT116 colon cancer cells.

Comments

Copyright 2022 Salahuddin Ahmed. All Rights Reserved.

https://go.openathens.net/redirector/utrgv.edu?url=https://www.proquest.com/dissertations-theses/fabrication-characterization-force-spun-polymeric/docview/2801855524/se-2?accountid=7119

Recommended Citation

Ahmed, Salahuddin, "Fabrication and Characterization of Force Spun Polymeric Nanofiber for Drug Delivery and Tissue Engineering Applications" (2022). Theses and Dissertations. 1116.
https://scholarworks.utrgv.edu/etd/1116