Theses and Dissertations

Date of Award

12-2022

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Biochemistry and Molecular Biology

First Advisor

Dr. Meena Jaggi

Second Advisor

Dr. Subhash Chauhan

Third Advisor

Dr. Murali Yallapu

Abstract

Pancreatic cancer is the seventh leading cause of cancer-related mortality worldwide. According to the American Cancer Society, it is the eleventh most common cancer diagnosed in both men and women in the United States. Pancreatic ductal adenocarcinoma (PDAC) comprises 90% of all pancreatic malignancies and is associated with poor clinical outcome because of late diagnosis and resistance to therapy. In addition, studies show that the tumor microenvironment has become an emerging interest in cancer research due to its complex components and unique characteristics that aid in cancer initiation, maintenance, and progression. Accumulating evidence signifies that tumor associated macrophages (TAMs) play a vital role in cancer progression by initiating an immunosuppressive microenvironment. In our lab, we have identified that PKD1, a serine/threonine kinase responsible for regulating multiple biological cell functions, is responsible for increasing tumorigenesis and upregulating glucose metabolism in pancreatic cancer. First, we investigated the effect that aberrant glucose metabolism had on macrophage polarization, finding that induced glucose and lactic acid conditions drove macrophages towards a pro tumorigenic phenotype. Further, we found that overexpressing PKD1 increases invasion, migration, and proliferation of KPC cells.

Comments

Copyright 2022 Anyssa A. Rodriguez. All Rights Reserved.

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