Theses and Dissertations

Date of Award

12-2023

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Biology

First Advisor

Bilal Hafeez

Second Advisor

Dae Kim

Third Advisor

Megan Keniry

Abstract

Prostate cancer (PrCa) is one of the most common malignancies in men globally and the second leading cause of cancer associated deaths in developed countries. Accumulating evidence have demonstrated involvement of various molecular and cellular factors in the development, progression and chemoresistance of PrCa and many of them were successfully established as potential molecular targets for therapy. Despite these advancements, the underlying mechanisms of PrCa occurrence is still unclear, which limits the diagnosis and therapy. Therefore, it is an urgent need to discover potential molecular targets which can be used in rational design of new strategies for the prevention and treatment of cancer. Cancer cells require high demand of protein synthesis for their survival. Aberrant regulation of ribosome biogenesis occurs in cancer cells which makes it a promising target for cancer therapy. The UBTF (upstream binding transcription factor) gene encodes a member of the HMG-box DNA-binding protein family, which plays a critical role in the process of ribosome biogenesis and is linked to cancer. However, no study has defined its role in PrCa. In this study, we for the first time show that UBTF is overexpressed in prostate tumor tissues when compared to normal prostate tissue, and its expression correlated with the progression of PrCa. We also observed that targeted knockdown of UBTF inhibits the growth of PrCa cells.

Comments

Copyright 2023 Guillermo Andres Saldana. All Rights Reserved.

https://go.openathens.net/redirector/utrgv.edu?url=https://www.proquest.com/dissertations-theses/overexpression-ubtf-correlates-with-aggressive/docview/2928456967/se-2?accountid=7119

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