Theses and Dissertations

Date of Award

12-1-2024

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Biochemistry and Molecular Biology

First Advisor

Dae Joon Kim

Second Advisor

Bilal Bin Hafeez

Third Advisor

Megan Keniry

Abstract

T-cell protein tyrosine phosphatase (TC-PTP) is a non-receptor PTP that has been shown to have various roles in signaling pathways. Our previous studies have demonstrated that the TC-PTP deficiency in the epidermis can exacerbate hyperplastic response by inducing epidermal cell proliferation in response to tumor promoter TPA or UVB exposure. This implies that TC-PTP plays a tumor-suppressive role in the epidermis and provides protection against UVB radiation, which is well known to contribute to skin cancer development. The p38 mitogen-activated protein kinase (MAPK) is one of serine/threonine kinases that are activated through environmental stress including UVB. It has been demonstrated to play a crucial role in mediating inflammatory responses and apoptosis following UVB exposure. In the present study, we aim to elucidate the molecular mechanisms by which TC-PTP influences the p38 MAPK pathway and its subsequent effects on cellular responses to UVB exposure.

Comments

Copyright 2024 Lindsey Shim. https://proquest.com/docview/3153372755

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