Theses and Dissertations
Date of Award
Master of Science (MS)
Dr. Karen Lozano
Dr. Robert Gilkerson
Dr. Rogelio Benitez
This thesis presents the successful development of biocompatible Polyvinyl Butyral (PVB), PVB/Polylysine and PVB/Tannic Acid (TA)/Polylysine fibers from an ethanol solution, Polyhydroxybutyrate (PHB), PHB/Polylysine, PHB/TA/Polylysine fibers from a chloroform solution and Chitosan (CH)/Pullulan (PL)/TA and CH/PL/TA/Polylysine fibers from an aqueous solution. The fibers were mass produced utilizing the Forcespinning® (FS) technology. The morphology of the fibers was characterized using a scanning electron microscope (SEM) and the fibers average diameter was calculated. The thermal properties of the fibers were characterized using a thermogravimetric analyzer (TGA) and a differential scanning calorimeter (DSC). The antibacterial activity of the fibers was assessed using against Escherichia coli. The biocompatibility of the fibers was studied by culturing NIH 3T3 Mouse Embryonic Fibroblast cells in the fibers. These fibers provide the cells with a 3D environment mimicking the extracellular matrix (ECM) in the skin which favors cell adherence and attachment, thus favoring skin wound healing.
Rodriguez Negron, Astrid Michelle, "Fibers for Skin Regeneration" (2018). Theses and Dissertations. 391.
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