The DMAP-Catalyzed Acylation of Alcohol -- A Mechanistic Study

Author

Tania Veronica Alvarez Castro, The University of Texas Rio Grande Valley

Date of Award

12-2020

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Dr. R. Erik Plata

Second Advisor

Dr. Arnulfo Mar

Third Advisor

Dr. Jason Parsons

Abstract

The mechanistic studies of Acylation of Alcohols catalyzed by 4-(N,N- Dimethyl-amino)-pyridine (DMAP) has been heavily studied in the literature. This reaction has attracted considerable interest from the synthetic and mechanistic points of view in recent years. In this research, the acylation of alcohols is prepared from cyclohexanol and acetic anhydride that is catalyzed by DMAP using triethyl amine (NEt3) as the auxiliary base and dichloromethane (DCM) as solvent. The reaction and final product will be analyzed by using gas chromatography (GC) and reaction progress kinetic analysis (RPKA). The mechanistic insights obtained in the present study should be useful for understanding the acylation of alcohols, and hence, provide valuable information.

Comments

Copyright 2020 Tania Veronica Alvarez Castro. All Rights Reserved.

https://go.openathens.net/redirector/utrgv.edu?url=https://www.proquest.com/dissertations-theses/dmap-catalyzed-acylation-alcohol-mechanistic/docview/2507163637/se-2?accountid=7119

Recommended Citation

Alvarez Castro, Tania Veronica, "The DMAP-Catalyzed Acylation of Alcohol -- A Mechanistic Study" (2020). Theses and Dissertations. 608.
https://scholarworks.utrgv.edu/etd/608