Theses and Dissertations

Date of Award

12-2020

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Biochemistry and Molecular Biology

First Advisor

Dr. Chun Xu

Second Advisor

Dr. Gladys Maestre

Third Advisor

Dr. Mario Gil

Abstract

The purpose of this study was to assess the impact of phenotypic variables and Apolipoprotein E (APOE) alleles and its effect on cognitive statues. APOE is a gene found vastly in the Hispanic community, speculated to be linked to neurodegenerative disorders such as Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI). Compared demographic, clinical, and genetic features among Hispanics who were diagnosed with Alzheimer's Disease, Mild Cognitive Impairment, and psychiatric disorders (e.g., anxiety and depression) in the efforts to assess the role of APOE. In past research, APOE has been considered a pathological hallmark for neurological diseases.

Past research has demonstrated that Hispanics have a younger age onset of neurodegenerative disorders and more clinical symptoms. In this research, is meant to test the association of the APOE variant 2, variant 3, and variant 4 alleles across the different cognitive statues; additionally, determining the association of APOE with gender, age, education and BMI.

Comments

Copyright 2020 Kimberly Moreno. All Rights Reserved.

https://go.openathens.net/redirector/utrgv.edu?url=https://www.proquest.com/dissertations-theses/association-study-apoe-alleles-with/docview/2555680757/se-2?accountid=7119

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