Date of Award
Master of Science (MS)
Biochemistry and Molecular Biology
Dr. Chun Xu
Dr. Gladys Maestre
Dr. Mario Gil
The purpose of this study was to assess the impact of phenotypic variables and Apolipoprotein E (APOE) alleles and its effect on cognitive statues. APOE is a gene found vastly in the Hispanic community, speculated to be linked to neurodegenerative disorders such as Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI). Compared demographic, clinical, and genetic features among Hispanics who were diagnosed with Alzheimer's Disease, Mild Cognitive Impairment, and psychiatric disorders (e.g., anxiety and depression) in the efforts to assess the role of APOE. In past research, APOE has been considered a pathological hallmark for neurological diseases.
Past research has demonstrated that Hispanics have a younger age onset of neurodegenerative disorders and more clinical symptoms. In this research, is meant to test the association of the APOE variant 2, variant 3, and variant 4 alleles across the different cognitive statues; additionally, determining the association of APOE with gender, age, education and BMI.
Moreno, Kimberly, "Association Study: APOE Alleles Association with Neurodegenerative Disorders in the Hispanic Population" (2020). Theses and Dissertations. 725.