Theses and Dissertations
Characterization of Biomarkers for Alzheimer’s Disease and HIV-1 Associated Neurocognitive Disorders
Date of Award
12-2021
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Biochemistry and Molecular Biology
First Advisor
Dr. Upal Roy
Second Advisor
Dr. Hansapani Rodrigo
Third Advisor
Dr. Mario Gil
Abstract
Alzheimer’s disease is a neurodegenerative disorder that is characterized by progressive cognitive decline and the accumulation of amyloid beta and neurofibrillary tangles in regions of the brain. These protein deposits are known to generate multiple effects on the brain that lead to neurodegeneration. It has been established that (Human Immunodeficiency Virus) HIV-1 accelerates the aging process of people living with HIV-1. Moreover, there is significant clinical evidence indicating a potential link between the neurodegeneration developed by those with an HIV-1 infection and AD. HIV-1 viral infection causes cognitive impairment known as HIV-associated neurocognitive disorders. Most of the underlying mechanism between HAND and AD is not well characterized. This study explores the possibility of identifying common differentially expressed genes, that may serve as biomarkers for early detection or intervention Transcriptome profiles of both pathologies will be used in order to identify biomarkers that will be further explored using Alzheimer’s disease models.
Recommended Citation
Garces, Armando III, "Characterization of Biomarkers for Alzheimer’s Disease and HIV-1 Associated Neurocognitive Disorders" (2021). Theses and Dissertations. 866.
https://scholarworks.utrgv.edu/etd/866
Included in
Biochemistry, Biophysics, and Structural Biology Commons, Medicine and Health Sciences Commons
Comments
Copyright 2021 Armando Garces III. All Rights Reserved.
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