Theses and Dissertations

Date of Award


Document Type


Degree Name

Master of Science (MS)


Biochemistry and Molecular Biology

First Advisor

Dr. Upal Roy

Second Advisor

Dr. Hansapani Rodrigo

Third Advisor

Dr. Mario Gil


Alzheimer’s disease is a neurodegenerative disorder that is characterized by progressive cognitive decline and the accumulation of amyloid beta and neurofibrillary tangles in regions of the brain. These protein deposits are known to generate multiple effects on the brain that lead to neurodegeneration. It has been established that (Human Immunodeficiency Virus) HIV-1 accelerates the aging process of people living with HIV-1. Moreover, there is significant clinical evidence indicating a potential link between the neurodegeneration developed by those with an HIV-1 infection and AD. HIV-1 viral infection causes cognitive impairment known as HIV-associated neurocognitive disorders. Most of the underlying mechanism between HAND and AD is not well characterized. This study explores the possibility of identifying common differentially expressed genes, that may serve as biomarkers for early detection or intervention Transcriptome profiles of both pathologies will be used in order to identify biomarkers that will be further explored using Alzheimer’s disease models.


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