Date of Award
Master of Science (MS)
Biochemistry and Molecular Biology
Dr. Upal Roy
Dr. Hansapani Rodrigo
Dr. Mario Gil
Alzheimer’s disease is a neurodegenerative disorder that is characterized by progressive cognitive decline and the accumulation of amyloid beta and neurofibrillary tangles in regions of the brain. These protein deposits are known to generate multiple effects on the brain that lead to neurodegeneration. It has been established that (Human Immunodeficiency Virus) HIV-1 accelerates the aging process of people living with HIV-1. Moreover, there is significant clinical evidence indicating a potential link between the neurodegeneration developed by those with an HIV-1 infection and AD. HIV-1 viral infection causes cognitive impairment known as HIV-associated neurocognitive disorders. Most of the underlying mechanism between HAND and AD is not well characterized. This study explores the possibility of identifying common differentially expressed genes, that may serve as biomarkers for early detection or intervention Transcriptome profiles of both pathologies will be used in order to identify biomarkers that will be further explored using Alzheimer’s disease models.
Garces, Armando III, "Characterization of Biomarkers for Alzheimer’s Disease and HIV-1 Associated Neurocognitive Disorders" (2021). Theses and Dissertations. 866.