Theses and Dissertations

Date of Award

5-2021

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Biochemistry and Molecular Biology

First Advisor

Dr. Upal Roy

Second Advisor

Dr. Sue Anne Chew

Third Advisor

Dr. Alejandro Lopez-Juarez

Abstract

While HIV-1 treatment has been revolutionized by combination antiretroviral therapy in the past two decades, HIV-1 remains persistent in organs that don’t allow easy penetration of anti-HIV drugs (e.g., brain) and cause persistent HIV-1 infections and inflammation. Researchers have turned towards nanotechnology-based drug carriers to combat this challenge, such as nanodiscoidal bicelles (ND) and liposomes. Bicelles entrap the drug in their interior hydrophobic core until metabolized by the body, and the payload can be released at the desired location in a controlled, long-lasting dosage. This study investigated the toxicity and extended-release of an anti-HIV drug-loaded within ND and liposomes for HIV-1 treatment to the brain. Results from both in-vitro and in-vivo characterization studies demonstrated that further optimization of the ND formulation needs to be adjusted towards liposomal structures for future studies.

Comments

Copyright 2021 Caroline Garcia. All Rights Reserved.

https://go.openathens.net/redirector/utrgv.edu?url=https://www.proquest.com/dissertations-theses/development-tenofovir-loaded-nanodisc-liposome/docview/2699740664/se-2?accountid=7119

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