Theses and Dissertations - UTRGV

Date of Award


Document Type


Degree Name

Master of Science (MS)



First Advisor

Dr. Shizue Mito

Second Advisor

Dr. Nirakar Sahoo

Third Advisor

Dr. Jose J. Gutierrez


The purpose of the research was to synthesize the E stereoisomer of Bilirubin Oxidation Products that had not been synthesized through a total organic synthesis at the start of this project. There were numerous different procedures for the bromination of citraconic anhydride performed in an attempt to optimize yield and purity. A proposed scheme for the total synthesis of the E isomers was constantly updated and altered while the project was ongoing. The bioactivity of the compounds was to be tested if the project had been finished. This might have contributed to a greater understanding of their function and association with subarachnoid hemorrhage induced vasospasm.


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