The Role of TC-PTP in UVB-Induced Skin Differentiation

Authors

Smaran SR Marupudi, The University of Texas Rio Grande ValleyFollow
Jared Hensley, The University of Texas Rio Grande ValleyFollow
Dae Joon Kim, The University of Texas Rio Grande ValleyFollow

Document Type

Article

Publication Date

7-2024

Abstract

UVB radiation disrupts epidermal cell homoeostasis by activating T-cell PTP (TC-PTP), which inhibits proliferation pathways and promotes apoptosis, thereby helping prevent skin cancer. TC-PTP also enhances epidermal differentiation, reducing cell mitotic potential. Our initial results show increased differentiation markers and apoptosis in TC-PTP-overexpressing cells, with further studies ongoing.

Recommended Citation

Marupudi, Smaran SR; Hensley, Jared; and Joon Kim, Dae, "The Role of TC-PTP in UVB-Induced Skin Differentiation" (2024). MEDI 8127 Scholarly Activities Pre-Clerkship. 64.
https://scholarworks.utrgv.edu/som8127/64

Academic Level

medical student

Mentor/PI Department

Immunology and Microbiology