Document Type
Article
Publication Date
7-2024
Abstract
This study investigates the role of T-cell protein tyrosine phosphatase (TC-PTP) in environmentally-induced epidermal differentiation and its implications for skin cancer progression. TC-PTP, encoded by the PTPN2 gene, is known to regulate phosphotyrosine signaling pathways involving STAT3. Using wild-type FBV-1 and TC-PTP overexpressed TG4-1 cells, we treated the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) at various intervals and examined morphological changes. Our results showed that TC-PTP overexpressed cells exhibited greater differentiation, with increased expression of cytokeratin 1, TG3, and involucrin, while wild-type cells displayed higher levels of proliferation markers PCNA and Ki67. These preliminary findings will be fully presented at the September UTRGV School of Medicine Research Symposium in poster format, with these findings also being included in a larger manuscript authored by Dr. Dae Joon Kim. These findings suggest that TC-PTP is critical in modulating epidermal differentiation in response to environmental stimuli, offering potential insights into skin cancer prevention strategies.
Recommended Citation
Hensley, Jared; Marupudi, Smaran SR; Shim, Lindsey; and Joon Kim, Dae, "The Role of T-cell Protein Tyrosine Phosphatase in Environmentally-Induced Epidermal Differentiation and Skin Cancer Progression" (2024). MEDI 8127 Scholarly Activities Pre-Clerkship. 65.
https://scholarworks.utrgv.edu/som8127/65
Academic Level
medical student
Mentor/PI Department
Immunology and Microbiology