School of Medicine Publications and Presentations
Document Type
Article
Publication Date
10-1-2012
Abstract
Why do memory abilities vary so greatly across individuals and cognitive domains? Although memory functions are highly heritable, what exactly is being genetically transmitted? Here we review evidence for the contribution of both common and partially independent inheritance of distinct aspects of memory function. We begin by discussing the assessment of long-term memory and its underlying neural and molecular basis. We then consider evidence for both specialist and generalist genes underlying individual variability in memory, indicating that carving memory into distinct subcomponents may yield important information regarding its genetic architecture. And finally we review evidence from both complex and single-gene disorders, which provide insight into the molecular mechanisms underlying the genetic basis of human memory function.
Recommended Citation
Bearden, C. E., Karlsgodt, K. H., Bachman, P., van Erp, T. G., Winkler, A. M., & Glahn, D. C. (2012). Genetic architecture of declarative memory: implications for complex illnesses. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 18(5), 516–532. https://doi.org/10.1177/1073858411415113
First Page
516
Last Page
32
Publication Title
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
DOI
10.1177/1073858411415113
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
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