School of Medicine Publications and Presentations
Document Type
Article
Publication Date
10-2012
Abstract
Background: Lipopolysaccharides (LPSs) up-regulate proinflammatory cytokines in macrophages, partly through a NF-κB-dependent process.
Results: Blocking neddylation, which helps regulate NF-κB, represses LPS-induced up-regulation of proinflammatory cytokines.
Conclusion: Neddylation plays a role in the up-regulation of NF-κB-regulated proinflammatory cytokines produced by macrophages in response to LPS.
Significance: Inhibition of neddylation represents a novel and effective method for the prevention of LPS-induced proinflammatory cytokines.
Recommended Citation
Chang, F. M., Reyna, S. M., Granados, J. C., Wei, S. J., Innis-Whitehouse, W., Maffi, S. K., Rodriguez, E., Slaga, T. J., & Short, J. D. (2012). Inhibition of neddylation represses lipopolysaccharide-induced proinflammatory cytokine production in macrophage cells. The Journal of biological chemistry, 287(42), 35756–35767. https://doi.org/10.1074/jbc.M112.397703
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Journal of Biological Chemistry
DOI
10.1074/jbc.M112.397703
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
Copyright © 2012 by The American Society for Biochemistry and Molecular Biology, Inc. Under a Creative Commons license