School of Medicine Publications and Presentations

Document Type


Publication Date



Background: Lipopolysaccharides (LPSs) up-regulate proinflammatory cytokines in macrophages, partly through a NF-κB-dependent process.

Results: Blocking neddylation, which helps regulate NF-κB, represses LPS-induced up-regulation of proinflammatory cytokines.

Conclusion: Neddylation plays a role in the up-regulation of NF-κB-regulated proinflammatory cytokines produced by macrophages in response to LPS.

Significance: Inhibition of neddylation represents a novel and effective method for the prevention of LPS-induced proinflammatory cytokines.


Copyright © 2012 by The American Society for Biochemistry and Molecular Biology, Inc. Under a Creative Commons license

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Title

Journal of Biological Chemistry



Academic Level


Mentor/PI Department

Office of Human Genetics



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