Systematic review and evidence gap mapping of Alzheimer's disease biomarker studies in those with intellectual and developmental disability

Authors

Lubnaa B. Abdullah, University of North Texas Health Science Center
Ney Alex Alliey, The University of Texas Rio Grande ValleyFollow
Emma Elizondo, The University of Texas Rio Grande Valley
Ney Alliey Rodriguez, The University of Texas Rio Grande ValleyFollow
Gladys Maestre, The University of Texas Rio Grande ValleyFollow
James Hall

Document Type

Article

Publication Date

9-2025

Abstract

There are a relatively small number of investigations into brain aging in those with intellectual and developmental disability (I/DD). This project seeks to (1) characterize the internationally available multi-omics Alzheimer's disease (AD) biomarker studies including those with I/DD, and (2) discuss future research directions. PubMed, Web of Science, and Scopus were searched under the following criteria: cross-sectional or longitudinal AD-omics studies on adults (18 +) with I/DD. 532 studies were identified, 186 studies were evaluated for full-text, 79 studies were excluded, and 117 studies were extracted. Most biological specimens were analyzed in blood, plasma, or serum. Metabolomics, hormonomics, and transcriptomics were most understudied. Sex differences were investigated in nine studies. Two studies included participants with non–Down syndrome neurodevelopmental disorders. European-based city populations were primarily represented across studies. Future studies including a broader range of I/DD presentations, and considering sex differences, comorbidities, and novel biomarkers beta synuclein are interesting future directions.

Comments

© 2025 The Author(s). Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.

Recommended Citation

Abdullah, L., Alliey, N. A., Elizondo, E., Alliey‐Rodriguez, N., Maestre, G., & Hall, J. (2025). Systematic review and evidence gap mapping of Alzheimer's disease biomarker studies in those with intellectual and developmental disability. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 17(3), e70175. https://doi.org/10.1002/dad2.70175

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Publication Title

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

DOI

10.1002/dad2.70175

Academic Level

faculty

Mentor/PI Department

Neuroscience