School of Medicine Publications and Presentations
Document Type
Article
Publication Date
9-2025
Abstract
There are a relatively small number of investigations into brain aging in those with intellectual and developmental disability (I/DD). This project seeks to (1) characterize the internationally available multi-omics Alzheimer's disease (AD) biomarker studies including those with I/DD, and (2) discuss future research directions. PubMed, Web of Science, and Scopus were searched under the following criteria: cross-sectional or longitudinal AD-omics studies on adults (18 +) with I/DD. 532 studies were identified, 186 studies were evaluated for full-text, 79 studies were excluded, and 117 studies were extracted. Most biological specimens were analyzed in blood, plasma, or serum. Metabolomics, hormonomics, and transcriptomics were most understudied. Sex differences were investigated in nine studies. Two studies included participants with non–Down syndrome neurodevelopmental disorders. European-based city populations were primarily represented across studies. Future studies including a broader range of I/DD presentations, and considering sex differences, comorbidities, and novel biomarkers beta synuclein are interesting future directions.
Recommended Citation
Abdullah, L., Alliey, N. A., Elizondo, E., Alliey‐Rodriguez, N., Maestre, G., & Hall, J. (2025). Systematic review and evidence gap mapping of Alzheimer's disease biomarker studies in those with intellectual and developmental disability. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 17(3), e70175. https://doi.org/10.1002/dad2.70175
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Publication Title
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
DOI
10.1002/dad2.70175
Academic Level
faculty
Mentor/PI Department
Neuroscience
Comments
© 2025 The Author(s). Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.