School of Medicine Publications and Presentations
Document Type
Article
Publication Date
8-30-2014
Abstract
Arsenic is the most toxic metalloid present in the natural environment in both organic and inorganic arsenic forms. Inorganic arsenic is often more hazardous than the organic form. Arsenite and arsenate compounds are the major inorganic forms which are toxic causing severe human health dysfunction including cancer. Excretion of arsenic from the system is found elusive. Therefore, it is of interest to screen channel proteins with the arsenic complex in the different combination of arsenic, GSH (glutathione) and arsenic, selenium using docking methods. The mode of arsenic removal. The complex structure revealed the mode of arsenic binding efficiency with the receptor aquaporine 9 and ABCC1 channel protein. This provides insights to understand the mechanism of arsenic efflux. These inferences find application in the design, identification and development of novel nutracetucal or any other formulation useful in the balance of arsenic efflux.
Recommended Citation
Poojan, S., Dhasmana, A., Jamal, Q. M., Haneef, M., & Lohani, M. (2014). Comparative Molecular Docking Studies with ABCC1 and Aquaporin 9 in the Arsenite Complex Efflux. Bioinformation, 10(8), 474–479. https://doi.org/10.6026/97320630010474
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Publication Title
Bioinformation
DOI
10.6026/97320630010474
Academic Level
faculty
Mentor/PI Department
Immunology and Microbiology
Comments
Copyright 2014 Biomedical Informatics