School of Medicine Publications and Presentations
Document Type
Article
Publication Date
1995
Abstract
The apolipoprotein 4 allele increases the risk of Alzheimer’s disease (AD), but cerebral deposition of B-amyloid with age, a genetic mutation, or head injury may contribute to the pathogenesis of this disease. We examined the risks of AD associated with traumatic head injury and apolipoprotein 4 in 236 community-dwelling elderly persons. A 10-fold increase in the risk of AD was associated with both apolipoprotein 4a nd a history of traumatic head injury, compared with a two-fold increase in risk with apolipoprotein 4 alone. Head injury in the absence of an apolipoprotein 4 allele did not increase risk. These data imply that the biological effects of head injury may increase the risk of AD, but only through a synergistic relationship with apolipoprotein 4.
Recommended Citation
Mayeux, R., Ottman, R., Maestre, G., Ngai, C., Tang, M.-X., Ginsberg, H., Chun, M., Tycko, B., & Shelanski, M. (1995). Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer’s Disease. Neurology, 45(3), 555. https://doi.org/10.1212/WNL.45.3.555
First Page
555
Last Page
557
Publication Title
Neurology
DOI
10.1212/WNL.45.3.555
Academic Level
faculty
Mentor/PI Department
Neuroscience
Comments
© 1995 by Modern Medicine Publications, Inc., a subsidiary of Edgell Communications, Inc. Original published version available at https://doi.org/10.1212/WNL.45.3.555