The apolipoprotein ϵ4 allele in Parkinson's disease with and without dementia

Authors

K. Marder
Gladys E. Maestre, The University of Texas Rio Grande ValleyFollow
L. Cote
H. Mejia
B. Alfaro
A. Halim
M. Tang
B. Tycko
R. Mayeux

Document Type

Article

Publication Date

7-1994

Abstract

The ϵ4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer's disease (AD). Because dementia in AD and Parkinson's disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and for 44 age-matched healthy elderly controls from the same community. We hypothesized that if the dementia was similar to AD, there would be a higher allele frequency of apolipoprotein ϵ4 (Apoϵ4) in demented PD patients compared with nondemented PD patients and controls. The ϵ4 allele frequency for PD without dementia was 0.132, for PD with dementia, 0.068, and for controls, 0.102. There was no association between Apoϵ4 and dementia in the PD patients. We conclude that the biologic basis for dementia in PD may differ from that of AD.

Comments

© 1994 by the American Academy of Neurology. Original published version available at https://doi.org/10.1212/WNL.44.7.1330

Recommended Citation

Marder, K., Maestre, G., Cote, L., Mejia, H., Alfaro, B., Halim, A., Tang, M., Tycko, B., & Mayeux, R. (1994). The apolipoprotein ϵ4 allele in Parkinson’s disease with and without dementia. Neurology, 44(7), 1330. https://doi.org/10.1212/WNL.44.7.1330

First Page

1330

Last Page

1331

Publication Title

Neurology

DOI

10.1212/wnl.44.7.1330

Academic Level

faculty

Mentor/PI Department

Neuroscience