School of Medicine Publications and Presentations
Document Type
Article
Publication Date
12-30-2021
Abstract
Von Willebrand Disease (VWD) is associated with significant morbidity as a result of excessive mucocutaneous bleeding symptoms. Patients with VWD can experience easy bruising, epistaxis, gastrointestinal and oral cavity bleeding, as well as heavy menstrual bleeding and bleeding after dental work, surgical procedures, and childbirth. Early diagnosis and treatment is important to prevent and treat these symptoms. We systematically reviewed the accuracy of diagnostic tests using different cut-off values of VWF:Ag and platelet-dependent VWF activity assays in the diagnosis of VWD. We searched Cochrane Central, MEDLINE, and EMBASE for eligible studies. Two investigators screened and abstracted data. Risk of bias was assessed using QUADAS-2 and certainty of evidence using the GRADE framework. We pooled estimates of sensitivity and specificity and reported patient important outcomes when relevant. This review included 21 studies that evaluated VWD diagnosis, including the approach to patients with VWF levels that have normalized with age (6 studies), VWF cut-off levels for the diagnosis of Type 1 VWD (9 studies), and platelet-dependent VWF activity/VWF:Ag ratio cut-off levels for the diagnosis of Type 2 VWD (6 studies). The results showed low certainty in the evidence for a net health benefit from reconsidering the diagnosis of VWD versus simply removing the disease in patients with VWF levels that have normalized with age. For the diagnosis of Type 1 VWD, in patients with VWF:Ag
Recommended Citation
Mohamad A. Kalot, Nedaa Husainat, Abdallah El Alayli, Omar Abughanimeh, Osama Diab, Sammy Tayiem, Bader Madoukh, Ahmad Bilal Dimassi, Aref Qureini, Barbara Ameer, Jeroen C.J. Eikenboom, Nicolas Giraud, Claire McLintock, Simon McRae, Robert R. Montgomery, James O'Donnell, Nikole Scappe, Robert F Sidonio, Romina Brignardello-Petersen, Veronica H Flood, Nathan T. Connell, Paula D. James, Reem A. Mustafa; Von Willebrand Factor Levels in The Diagnosis of Von Willebrand Disease: A Systematic Review and Meta-Analysis. Blood Adv 2021; bloodadvances.2021005430. doi: https://doi.org/10.1182/bloodadvances.2021005430
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Publication Title
Blood Advances
DOI
10.1182/bloodadvances.2021005430
Academic Level
faculty
Mentor/PI Department
Internal Medicine
Comments
Copyright © 2021 American Society of Hematology. Original published version available at https://doi.org/10.1182/bloodadvances.2021005430