School of Medicine Publications and Presentations
Document Type
Article
Publication Date
4-2020
Abstract
Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin resistance index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping and direct F/P differential gene expression in AT biopsies obtained from symptom-free adults from the GEMM family study. AT dysfunction was evaluated through associations of the ALR with F/P insulin-glucose axis, lipid-lipoprotein metabolism, and inflammatory markers. A relevant pattern of negative associations between decreased ALR and markers of systemic lowgrade metaflammation, HOMA, and postprandial cardiovascular risk hyperinsulinemic, triglyceride and GLP-1 curves was found. We also analysed their plasma non-coding microRNAs and shotgun lipidomics profiles finding trends that may reflect a pattern of adipose tissue dysfunction in the fed and fasted state. Direct gene differential expression data showed initial patterns of AT molecular signatures of key immunometabolic genes involved in AT expansion, angiogenic remodelling and immune cell migration. These data reinforce the central, early role of AT dysfunction at the molecular and systemic level in the pathogenesis of IR and immunometabolic disorders.
Recommended Citation
Rodriguez-Ayala, E., Gallegos-Cabrales, E. C., Gonzalez-Lopez, L., Laviada-Molina, H. A., Salinas-Osornio, R. A., Nava-Gonzalez, E. J., Leal-Berumen, I., Escudero-Lourdes, C., Escalante-Araiza, F., Buenfil-Rello, F. A., Peschard, V.-G., Laviada-Nagel, A., Silva, E., Veloz-Garza, R. A., Martinez-Hernandez, A., Barajas-Olmos, F. M., Molina-Segui, F., Gonzalez-Ramirez, L., Espadas-Olivera, R., … Bastarrachea, R. A. (2020). Towards precision medicine: Defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study. Adipocyte, 9(1), 153–169. https://doi.org/10.1080/21623945.2020.1743116
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
First Page
153
Last Page
169
Publication Title
Adipocyte
DOI
10.1080/21623945.2020.1743116
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Original published version available at https://doi.org/10.1080/21623945.2020.1743116